The European Agency for the Evaluation of Medicinal Products Veterinary Medicines and Information Technology

1. Cefoperazone is a third generation semi-synthetic cephalosporin with a broad spectrum of activity against the majority of aerobic and anaerobic gram-positive and gram-negative pathogenic bacteria in vitro. Cefoperazone sodium and -dihydrate are used for intramammary treatment of clinical mastitis in lactating cattle. Dose levels used are 250 mg cefoperazone sodium per infected quarter once or 100 mg cefoperazone dihydrate per infected quarter twice with a dosing interval of 24 hours.